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Active Trials in Locations

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Currently Enrolling
Interventional

FeaturedThe purpose of this Phase 2 adaptive study is to evaluate PF-06730512 following multiple intravenous infusions in adults with FSGS. The intention is to evaluate drug safety, as well as to obtain an early indication of effectiveness (how well the drug works at improving Urine Protein to Creatinine Ratio, which is a marker of kidney damage).

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Currently Enrolling
Observational

Cure Glomerulonephropathy (CureGN) is a multicenter five-year observational study of glomerular disease patients.

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Currently Enrolling
Observational

The Laboratory of Inherited Kidney Disease at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, Massachusetts, directed by Dr. Martin Pollak, seeks to identify genes that underlie the development of FSGS and similar diseases.

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Currently Enrolling
Interventional

The IGNAZ Study is looking at the safety and effectiveness of Felzartamab in adults 18 to 80 years old with IgA nephropathy. Researchers want to compare different doses of Felzartamab to see which one might be better than taking no medicine at all.

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Currently Enrolling
Interventional

The purpose of this study is to establish clinical proof-of-concept of effectiveness and to evaluate dose responses of the study drug in patients with IgAN.

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Currently Enrolling
Observational

The purpose of this study is to gather long-term observational data in order to help understand the biology behind nephrotic syndrome.

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Currently Enrolling
Interventional

Open-label, 2-arm, multicenter clinical trial to assess safety, efficacy and PK/PD of MOR202 in anti-PLA2R antibody positive membranous nephropathy (aMN)

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Currently Enrolling
Interventional

Phase II Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G (Complement 3 glomerulopathy) or IC-MPGN (immune-complex membranoproliferative glomerulonephritis)

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Currently Enrolling
Interventional

This Phase 3 study will determine is OMS721 is safe and effective at reducing symptoms for patients with IgAN.

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Currently Enrolling
Interventional

The purpose of the study it to measure the effectiveness of the study medication at improving kidney function to prevent damage in people who have IgAN.

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Currently Enrolling
Interventional

This clinical research study is investigating a potential treatment option for adults of African or Caribbean descent with biopsy-confirmed focal segmental glomerulosclerosis (FSGS). Testing for the APOL1 gene is included in this clinical study.

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Currently Enrolling
Interventional

The AFFINITY study is testing atrasentan, an investigational medication that has the potential to reduce proteinuria and preserve kidney function in patients with IgA nephropathy, focal segmental glomerulosclerosis, Alport Syndrome, and diabetic kidney disease.

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Currently Enrolling
Interventional

The ALIGN study is testing atrasentan, an investigational medication that has the potential to reduce proteinuria and preserve kidney function in patients with IgA nephropathy.

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Currently Enrolling
Interventional

Liposorber LA-15 System is a blood processing system used outside of the body. This device removes certain lipoproteins (LDL/BDL) from the patient's blood. The Liposorber LA-15 System is used in patients diagnosed with focal segmental glomerulosclerosis (FSGS.) either before transplant, or after a kidney transplant in which there is a recurrence of FSGS.

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Currently Enrolling
Interventional

Liposorber LA-15 System is a blood processing system used outside of the body. This device removes certain lipoproteins (LDL/BDL) from the patient's blood. The Liposorber LA-15 System is used in patients diagnosed with focal segmental glomerulosclerosis (FSGS.) either before transplant, or after a kidney transplant in which there is a recurrence of FSGS.

The study is ongoing at pediatric sites.

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Currently Enrolling
Interventional

This clinical trial will evaluate the efficacy of Nefecon compared to matching placebo in patients with primary IgAN on a background of optimized RAS inhibitor therapy.

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Currently Enrolling
Observational

The Rare Genomes Project aims to increase rare and undiagnosed families’ access to genomic research, empowering patients to directly accelerate the pace of rare disease diagnosis. This project was designed to be a direct partnership between researchers and patients, so we can better understand their conditions.

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Currently Enrolling
Observational

The TANGO study aims to create a large international network of centers to study glomerular disease (GN) recurrence after renal transplantation.

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Currently Enrolling
Interventional

GFB-887-201 is an interventional study comparing GFB-887 to placebo in patients with focal segmental glomerulosclerosis (FSGS), treatment-resistant minimal change disease (TR-MCD), and diabetic nephropathy (DN).

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Frequently Asked Questions

Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

Common symptoms include:

  • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
  • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
  • Weight gain due to a buildup of extra fluid
  • Fatigue
  • Loss of appetite
  • Low levels of protein in the blood (hypoalbuminemia)
  • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

Nephrotic Syndrome can typically be diagnosed with a urine test.

Nephrotic Syndrome can be “primary” or “secondary” in nature.

Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

  • Minimal Change Disease (MCD) – most common in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Membranous Nephropathy (MN) – most common in adults
  • IgA Nephropathy (IgAN)

Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

The Kidney Health Gateway is a website owned and operated by NephCure Kidney International. The purpose of this website is to help patients with rare forms of primary Nephrotic Syndrome get connected to expert care and cutting-edge treatment options. By answering a few questions about you or your loved one’s condition, we can provide you with a list of clinical trials and/or expert doctors in your area.

If you have additional questions, please visit NephCure.org or email Info@NephCure.org.

 

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Did you know that some forms of kidney disease can be genetic?Researchers are continually discovering genetic causes of Nephrotic Syndrome.

Learn more about genetic causes of kidney disease and find out if you may be affected.