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The TANGO Study

The TANGO Study for Post-Transplant Glomerular Diseases

Brief Description

The TANGO study aims to create a large international network of centers to study glomerular disease (GN) recurrence after renal transplantation.

Trial for people with

The TANGO study will enroll adult (≥18 years) patients with a biopsy-proven primary Glomerular Disease (IgA nephropathy, Membranous glomerulonephritis, Focal and segmental glomerulosclerosis, Atypical hemolytic uremic syndrome, Membranoproliferative glomerulonephritis old classification type I-III, Complement- or IgG-positive membranoproliferative, glomerulonephritis, Dense-deposit disease, C3 glomerulonephritis) as the designated cause of their end-stage kidney disease who underwent a kidney transplant starting in January 2005 or later.

Study Goal

The purpose of the TANGO study is to create a large international network of centers to study kidney disease that recur after renal transplantation. Since many of these kidney diseases that recur are rare, it is crucial that we involve many centers around the world to collect individualized information that will help to understand the disease and identify new treatments.

What is involved for the Patient?

Your clinical information and samples (blood and urine) will be analyzed anonymously. This will help better understand individual diseases and potentially identify new potential treatments. You may choose to be contacted in the future as discoveries are made and potential novel treatments become available for your condition.

About the drug or intervention

Learn more at

  • Study CoordinatorThe TANGO Study Team
  • Study Coordinator
  • Study Coordinator Phone617-525-8008
    If there is not a site for a clinical trial nearby, you can ask the study team about the possibility of travel reimbursements (i.e., paying you back for your travel costs). Alternatively, you can ask about the possibility of participating from home.
    Frequently Asked Questions

    Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

    Common symptoms include:

    • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
    • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
    • Weight gain due to a buildup of extra fluid
    • Fatigue
    • Loss of appetite
    • Low levels of protein in the blood (hypoalbuminemia)
    • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

    Nephrotic Syndrome can typically be diagnosed with a urine test.

    Nephrotic Syndrome can be “primary” or “secondary” in nature.

    Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

    • Minimal Change Disease (MCD) – most common in children
    • Focal Segmental Glomerulosclerosis (FSGS)
    • Membranous Nephropathy (MN) – most common in adults
    • IgA Nephropathy (IgAN)

    Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

    The Kidney Health Gateway is a website owned and operated by NephCure Kidney International. The purpose of this website is to help patients with rare forms of primary Nephrotic Syndrome get connected to expert care and cutting-edge treatment options. By answering a few questions about you or your loved one’s condition, we can provide you with a list of clinical trials and/or expert doctors in your area.

    If you have additional questions, please visit or email


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