Do you have a rare kidney disease like FSGS, IgA Nephropathy, or other Nephrotic Syndrome condition? You’ve come to the right place.
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Currently Enrolling
Birmingham, AL
The PODO Trial

Trial To Evaluate PF-06730512 In Adults With Primary Focal Segmental Glomerulosclerosis

Brief Description

The purpose of this Phase 2 adaptive study is to evaluate PF-06730512 following multiple intravenous infusions in adult patients with primary FSGS. In addition, the intention is to obtain an early indication of efficacy (how well the drug works at improving Urine Protein to Creatinine Ratio, which is a marker of kidney damage).

Trial for people with

Primary focal segmental glomerulosclerosis (FSGS)

Study Goal

To evaluate the safety, tolerability, and possibily efficacy of PF-06730512 in patients with FSGS.

What is involved for the Patient?

Patients will participate for about 8.5 months, and will receive the study drug by intravenous infusion every 2 weeks over a 12 week period.

About the drug or intervention

PF-06730512 works as an antagonist, meaning it possibly reduces the biologic activity that is associated with FSGS.

  • Study CoordinatorVickie Smith, RN
  • Study Coordinator
  • Study Coordinator Phone1-800-718-1021
  • Site NameUniversity of Alabama at Birmingham
  • Address2000 6th Avenue South, Birmingham, AL 35233
  • SponsorPfizer Inc.
  • Study DrugPF-06730512
  • Estimated enrollment44
  • Estimated end dateMay, 2021
If there is not a site for a clinical trial nearby, you can ask the study team about the possibility of travel reimbursements (i.e., paying you back for your travel costs). Alternatively, you can ask about the possibility of participating from home.
Frequently Asked Questions

Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

Common symptoms include:

  • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
  • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
  • Weight gain due to a buildup of extra fluid
  • Fatigue
  • Loss of appetite
  • Low levels of protein in the blood (hypoalbuminemia)
  • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

Nephrotic Syndrome can typically be diagnosed with a urine test.

Nephrotic Syndrome can be “primary” or “secondary” in nature.

Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

  • Minimal Change Disease (MCD) – most common in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Membranous Nephropathy (MN) – most common in adults
  • IgA Nephropathy (IgAN)

Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

The Kidney Health Gateway is a website owned and operated by NephCure Kidney International. The purpose of this website is to help patients with rare forms of primary Nephrotic Syndrome get connected to expert care and cutting-edge treatment options. By answering a few questions about you or your loved one’s condition, we can provide you with a list of clinical trials and/or expert doctors in your area.

If you have additional questions, please visit or email


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