Do you have a rare kidney disease like FSGS, IgA Nephropathy, or other Nephrotic Syndrome condition? You’ve come to the right place.
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Currently Enrolling
Boston, MA
The LUMINA Studies for FSGS Patients

A Study of CCX140-B in Subjects With FSGS

Brief Description

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Study to Evaluate the Safety and Efficacy of CCX140-B in Subjects with FSGS to be conducted in the North America, Europe and Australia

Trial for people with

Primary focal segmental glomerulosclerosis (FSGS)

Study Goal

The aim of this study is to evaluate the effect of treatment with CCX140-B in patients with focal segmental glomerulosclerosis on urinary protein excretion, which will be measured by changes in UPCR.

What is involved for the Patient?

Patients will be assigned to one of four study groups and will receive either placebo or a varying dose of the study drug to take daily.

About the drug or intervention

CCX140-B is a selective antagonist of C-C chemokine receptor 2.

  • Study CoordinatorPeter Staehr, MD & Erin P. Kohnson, BA
  • Study Coordinator
  • Study Coordinator Phone650-210-2903
  • Site NameMassachusetts General Hospital
  • Address55 Fruit Street
  • SponsorChemoCentryx, Inc.
  • Study DrugCCX140-B
  • Estimated enrollment40
  • Estimated end dateJuly, 2019
If there is not a site for a clinical trial nearby, you can ask the study team about the possibility of travel reimbursements (i.e., paying you back for your travel costs). Alternatively, you can ask about the possibility of participating from home.
Frequently Asked Questions

Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

Common symptoms include:

  • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
  • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
  • Weight gain due to a buildup of extra fluid
  • Fatigue
  • Loss of appetite
  • Low levels of protein in the blood (hypoalbuminemia)
  • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

Nephrotic Syndrome can typically be diagnosed with a urine test.

Nephrotic Syndrome can be “primary” or “secondary” in nature.

Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

  • Minimal Change Disease (MCD) – most common in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Membranous Nephropathy (MN) – most common in adults
  • IgA Nephropathy (IgAN)

Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

The Kidney Health Gateway is a website owned and operated by NephCure Kidney International. The purpose of this website is to help patients with rare forms of primary Nephrotic Syndrome get connected to expert care and cutting-edge treatment options. By answering a few questions about you or your loved one’s condition, we can provide you with a list of clinical trials and/or expert doctors in your area.

If you have additional questions, please visit or email


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